2), 44–47. J. 101 (5), 1314–1319. Su principio activo, el carvacrol y el timol, son importantes antioxidantes y pueden ayudar a reforzar la función inmune. Mol. The literature reveals that AFP, besides being one of the most useful biomarkers for the detection of hepatocellular carcinoma, also serves to monitor the response to anticancer therapy (high levels indicate tumor progression) (Bei and Mizejewski, 2011; Wong et al., 2015; Wang and Wang, 2018). Targets 19 (1), 113–127. doi:10.1136/jmg.2009.066944, Ghorani, V., Alavinezhad, A., Rajabi, O., Mohammadpour, A. H., and Boskabady, M. H. (2021). In Vitro effects of Two Major Phenolic Compounds from the Family Lamiaceae Plants on the Human Gastric Carcinoma Cells. 7 (4), 189–194. Pharmaceuticals 13 (11), 405. doi:10.3390/ph13110405, Sivaranjani, A., Sivagami, G., and Nalini, N. (2016). (2016). The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2021.702487/full#supplementary-material, Abbas, A., and Al-Fatlawi, A. 8600 Rockville Pike The Influence of Different Oregano Species on the Antioxidant Activity Determined Using HPLC Postcolumn DPPH Method and Anticancer Activity of Carvacrol and Rosmarinic Acid. Biophysical Res. Presencia en la naturaleza. doi:10.21873/anticanres.12219, Kang, S.-H., Kim, Y.-S., Kim, E.-K., Hwang, J.-W., Jeong, J.-H., Dong, X., et al. Este método fue llevado por el método recuperación después de la adición de dos concentraciones de estándar 0,1 y 1,0 ug/mL de carvacrol y 0,7 y 7,0 μg/mL de timol. Food Sci. Carvacrol Exhibits Anti-oxidant and Anti-inflammatory Effects against 1, 2-dimethyl Hydrazine Plus Dextran Sodium Sulfate Induced Inflammation Associated Carcinogenicity in the colon of Fischer 344 Rats. Liolios, O. Gortzi, S. Lalas, J. Tsaknis, I. Chinou; Liposomal incorporation of carvacrol and thymol isolated from the essential oil of Origanum dictamnus L. and in vitro antimicrobial activity. (2019). (2011). In a prostate cancer cell line (DU 145), carvacrol showed a significant reduction of cell viability and proliferation in a concentration and time dependent manner, marked by a cell cycle arrest, resulting in the accumulation of cells in the G0/G1 phase, and apoptosis, related to the increased activity of caspase-3, production of ROS and loss of mitochondrial membrane potential (Khan et al., 2017). INTRODUCCIÓN: los patógenos resistentes a múltiples fármacos presentan un reto global importante en la terapia antimicrobiana y con frecuencia complican la otitis externa en perros. Disagreements were resolved through a consensus between the reviewers, and the decision was supported by the assistance of a third reviewer when necessary (AGG). Int. 3 (4), 294–300. Cytotoxic, Cytogenetics and Immunomodulatory Effects of Thymol from Thymus Vulgaris on Cancer and Normal Cell Lines In Vitro and In Vivo. Stem Cells 25 (5), 1090–1095. Plos Med. 69 (5), 1057–1065. (2018). 34 (3), 165–175. Our review also showed that carvacrol and its thymol isomer are capable of restraining growth and combating different tumor strains in vitro. 16 (5B), 3053–3058. To assess the risk of bias in in vivo studies, the SYRCLE Risk of Bias tool was used, and for in vitro studies, a modified version was used. Carvacrol Timol 80% Antes: 1789 pesos$ 1.789 1520 pesos$ 1.520 15% OFF Mismo precio en 3x de $506,88 Primal Fx Oregano Oil 80% Carvacrol Timol. León-Rodríguez, A. de, Escalante-Minakata, P., Jiménez-García, M. I., Ordoñez-Acevedo, L. G., Flores Flores, J. L. and Barba de la Rosa, A. P., Food Technology and Biotechnology, 2008, Volume 46, Number 4, pages 448-455 (, parte superior da página, em frente ao título do artigo, condições normais de temperatura e pressão, Referências e avisos gerais sobre esta caixa, «Carvacrol data sheet from Sigma-Aldrich», http://www.liu.edu/Brooklyn/About/News/Press-Releases/2012/April/BK-PR-Apr25-2012.aspx, http://www.hort.purdue.edu/newcrop/proceedings1993../V2-628.html, http://www.herbapolonica.pl/magazines-files/2733672-art.3.pdf, Journal of Radioanalytical and Nuclear Chemistry, https://pt.wikipedia.org/w/index.php?title=Carvacrol&oldid=57189741, !Artigos que necessitam de esclarecimento, !Artigos que incorporam texto da Encyclopædia Britannica, Atribuição-CompartilhaIgual 3.0 Não Adaptada (CC BY-SA 3.0) da Creative Commons, 25 bactérias e estirpes periodontopáticas diferentes, Este artigo incorpora texto (em inglês) da. Further studies are required to help unravel and define the mechanisms of action of the two compounds against cancer cells, as well as studies that further explore their chemopreventive and anti-metastatic effects. Biochem. (2020) established two in vivo models to investigate the effect of thymol on cancer progression. Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells. Li et al. Crit. Lancet Oncol. doi:10.1016/j.febslet.2006.08.025, Kroemer, G., Dallaporta, B., and Resche-Rigon, M. (1998). Hypothese/ziele: El carvacrol y el timol, compuestos fenólicos monoterpenos, son los principales responsables de la actividad antimicrobiana del AO (Zairi . FIGURE 7. However, this effect is very limited compared to the natural oregano oil. Inflammopharmacol 27 (6), 1275–1283. doi:10.1016/j.molmed.2017.02.001, Ghavami, S., Hashemi, M., Ande, S. R., Yeganeh, B., Xiao, W., Eshraghi, M., et al. (2016). Los resultados muestran que el protocolo desarrollado es un método adecuado para la determinación de timol y carvacrol en hojas de orégano. Sobre Nosotros, Diferencia entre policarbonato y plexiglás. doi:10.1002/iub.1879, Zhang, H., Liu, H., Iles, K. E., Liu, R.-M., Postlethwait, E. M., Laperche, Y., et al. Ther. doi:10.7314/apjcp.2015.16.5.1677, Rojas-Armas, J. P., Arroyo-Acevedo, J. L., Palomino-Pacheco, M., Herrera-Calderón, O., Ortiz-Sánchez, J. M., Rojas-Armas, A., et al. doi:10.1016/j.ejphar.2015.12.046, Binétruy, B., Heasley, L., Bost, F., Caron, L., and Aouadi, M. (2007). Similarly, the administration of thymol to lung cancer cells promoted a reduction in cell viability in the A549, H460 and H1299 cell lines (Pathania et al., 2013; Coccimiglio et al., 2016; De La Chapa et al., 2018; Balan et al., 2021). In Asia, the continent with the largest number of publications on the subject, the use of traditional, popular medicine continues to grow (De Boer and Cotingting, 2014) due to the low costs, easy access, the frequent reduced side effects and toxicity, and their better biodegradable properties (Soković et al., 2013). Food Chem. (2018) demonstrated that the cytotoxicity exhibited by carvacrol against HeLa cells occurred through the suppression of the cell cycle and induction of apoptosis, the latter accompanied by an increase in caspase-9, PARP cleavage, and activation of ERK, increasing the expression of phospho-ERK1/2. Para el desarrollo del método cromatográfico, se requiere una separación de los picos; se evaluó la resolución de los picos de timol y carvacrol. The Comparative Clinical Pharmacology and Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Human Patients with Cancer. Toxicol. doi:10.1016/j.semcancer.2017.04.015, Olsson, M., and Zhivotovsky, B. La determinación de timol y carvacrol en muestras de orégano y otras plantas, ha sido realizado por muchos autores utilizando métodos por HPLC 1-5 y cromatografía de gases con detector FID o de masas. PI3k belongs to a family of lipid kinases, involved in extracellular signals transduction and cell growth promotion (Wullschleger et al., 2006; Alzahrani, 2019). Método: el aceite esencial se obtuvo por hidrodestilación e hidrodestilación asistida por radiación con microondas, a partir de las hojas; se determinó densidad relativa a 20 . ¿Qué es el timol? (2014). Medicine: Stonehenge, 500–1450. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol and thymol. Treatment with carvacrol in leiomyosarcoma cells exhibited antiproliferative effects in a concentration dependent manner and also inhibition of cell growth (Karkabounas et al., 2006). [4] Propiedades. Eur. "; Conclusions and clinical significance: Se realizó un ensayo de cinética de tiempo de destrucción para confirmar la actividad bactericida y fungicida de los aceites y sus componentes fenólicos. J. Carvacrol/β-cyclodextrin Inclusion Complex Inhibits Cell Proliferation and Migration of Prostate Cancer Cells. Carvacrol y Timol de Orégano $ 281.00 -Trata infecciones respiratorias -Es un fuerte antibiótico natural -Atiende afecciones en la piel -Ayuda a combatir síntomas de la gastritis ESTAFILOFin ® Añadir al carrito Categoría: Cápsulas / tabletas Descripción Cápsulas 30 cáps. In their most recent study, Günes-Bayir et al. World J. Pharm. Todos os direitos reservados. This is a great barrier advances in this area of knowledge and helps to explain the discrepancy in the number of studies published in vitro (n = 69) and in vivo (n = 10) over the last two decades, as well as the absence of clinical trials. Historically, secondary plant metabolites have made important contributions to cancer therapy, such as, the vinca alkaloids (vinblastine and vincristine) and the paclitaxel terpene that was obtained from the Taxus brevifolia Nutt. (2016). Antioxidant, Antibacterial, and Cytotoxic Activities of the EthanolicOriganum vulgare Extract and its Major Constituents. B., et al. Asian Pac. El método de determinación es adecuado para la cuantificación del timol y carvacrol en muestras de hojas de orégano secadas al aire bajo sombre y extraídos por el método de Klevenger durante 2 horas. Pharmacol. Effect of Neoplasms on the Content and Activity of Alkaline Phosphatase and Gamma-Glutamyl Transpeptidase in Uninvolved Host Tissues. (2014). Germany: CABI. El timol (2- iso propil-5-methil-fenol) es una sustancia cristalina incolora con un olor característico que está presente en la naturaleza en los aceites esenciales del tomillo o del orégano. Of these, three were excluded after reading the full text (two for presenting the same results and one that tested the anti-cancer effect on bacteria) and four for not having access to the full text, resulting in 70 articles. Tomilho: veja para que serve a especiaria, Orégano: veja para que serve a especiaria, Candidíase: causas e tratamentos naturais, Remédios naturais para o tratamento da psoríase, O milho é considerado um dos alimentos mais, O chá de hibisco (Hibiscus sabdariffa) se to, Em estudos preliminares realizados em humanos, foi, O chá de hibisco é um dos chás mais popula, O morango é uma das frutas menos calóricas q, A curcumina é o principal ingrediente ativo do tu. Hosp. 8 (2), 105–116. Ther. A Useful Marker in the Diagnosis of Hepatocellular Carcinoma. In addition, cell cycle arrest, reported in 14.7% (n = 10) of in vitro studies also represents a promising target of cancer treatment, since natural compounds can act as modulators, interrupting the cell cycle and, therefore, killing cancer cells (Bailon-Moscoso et al., 2017). Federal government websites often end in .gov or .mil. 11 (9), 3980–3990. As a cell moves through each phase, stimulated by growth and transcription factors, it passes through several checkpoints, which ensure that mitosis occurs only when the cellular genome has been precisely replicated, avoiding mutations and generation of transformed cells (Hamilton and Infante, 2016; Ingham and Schwartz, 2017). 36 (11), 5757–5764. In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells. Careers. One hundred bacterial and fungal isolates, including meticillin-susceptible Staphylococcus pseudintermedius (n = 10), meticillin-resistant S. pseudintermedius (n = 10), β-haemolytic Streptococcus spp. More recently, Rojas-Armas et al. In vitro, methotrexate and vincristine (0.5 µg/100 µL) (Jaafari et al., 2007), 5-fluorouracil (5-FU) (2.6 μg/μM) (Maryam et al., 2015), doxorubicin (0.5, 5, 10, and 20 μg/mL) (Tayarani-Najaran et al., 2019) (1.0 μg/mL) (Ferraz et al., 2013) and (2 μM) (Kang et al., 2016), camptothecin (5 μM) (Deb et al., 2011) and in vivo, doxorubicin (2 mg/kg) (Zeng et al., 2020), were the main substances used to compare the potential therapeutic effect of these monoterpenes. Biol. pachydermatisの場合、MIC90 値は0.09〜0.25%(800〜2,292μg/ mL)の範囲に及んだ。 結論と臨床的重要性: オレガノ油、タイム油、カルバクロールおよびチモールは、外耳炎を有する犬から採材された100の分離株(いくつかの高度な薬剤耐性分離株を含む)に対し、in vitroにおいて良好な殺菌および殺菌活性を示した。これらの精油とその主要なフェノール成分は、犬外耳炎治療のに対し、in vivoでさらに調査される可能性を持っている。. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Perigo CV, Haber LL, Facanali R, Vieira MAR, Torres RB, Bernacci LC, Guimarães EF, Baitello JB, Sobral MEG, Quecini V, Marques MOM. Furthermore, supplementation with carvacrol significantly restored the activities of liver microsomal xenobiotic metabolizing enzymes to normal, with a reduced expression of proliferative nuclear cell antigen (PCNA), MMP-2 and -9, and thereby prevented the local spread of carcinogenic cells, showing an antimetastatic effect (Subramaniyan et al., 2014). El orégano silvestre es una planta conocida desde hace miles de años por sus propiedades culinarias y medicinales. The crop has adapted well over 2600 m.a.s.l. Biotechnol. The review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) (Page et al., 2021). Zehra A, Wani SM, Jan N, Bhat TA, Rather SA, Malik AR, Hussain SZ. In fact, carvacrol pre-treatment caused the disappearance of most tumoral foci and nodules, characterized by few neoplastic cells, suggesting a chemopreventive effect. Based on these data, we compiled the IC50 (μM) values determined 24 h after the incubation of the studied cells with carvacrol or thymol. Our results showed that 24.6% of in vitro studies (n = 17) and 10% of in vivo studies showed an increase in Bax levels after treatment with carvacrol or thymol. El equipo de HPLC utilizado es Hitachi Elite LaChromm, con el Software EZChrom Elite v3.3.2, equipado con bomba L-2130, válvula gradiente baja presión L-2130ACC, degasificadora L-2000ACC, Interface USB IFU, horno de columnas L-2350, Inyector manual 7725i-006, mezclador cuaternario de solventes; el detector utilizado fue el Hitachi FL Detector L-2485; se utilizó la longitud de onda de excitación: 230 nm, longitud de onda de emisión: 280 nm. The uncontrolled proliferation of cancer cells occurs due to their ability to prevent programmed cell death (apoptosis) (Olsson and Zhivotovsky, 2011; Dabrowska et al., 2016; Kim and Kim, 2018), that is responsible for eliminating aberrant proliferating cells or those with DNA damage/mutations (Dabrowska et al., 2016) (Figure 5). Molecules 22 (9), 1435. doi:10.3390/molecules22091435, Fan, K., Li, X., Cao, Y., Qi, H., Li, L., Zhang, Q., et al. doi:10.1016/j.ejphar.2011.08.017, Huang, H., Zhang, X.-F., Zhou, H.-J., Xue, Y.-H., Dong, Q.-Z., Ye, Q.-H., et al. (2020) showed a better effect of carvacrol at a dose of 100 mg/kg/day compared to the other doses tested (50 and 200 mg/kg/day) in female Holztman rats with breast cancer induced by 7,12-dimethylbenzanthracene (DMBA), showing a reduction of 4 (of 16) tumors, in addition to a 75% reduction in the frequency of tumors, a 67% reduction in incidence, an increase in tumor latency and a reduction in the average tumor volume and cumulative tumor volume (Rojas-Armas et al., 2020). 1. The Effect of Carvacrol on Healthy Neurons and N2a Cancer Cells: Some Biochemical, Anticancerogenicity and Genotoxicity Studies. Biochem. doi:10.1016/j.semcancer.2019.07.009, Arigesavan, K., and Sudhandiran, G. (2015). P38 can also directly affect tumor invasion and angiogenesis (Wagner and Nebreda, 2009). In SiHa cells, the reduction in viability and apoptosis induction occurred through p53 activation and Bax, caspase-3, -6, -9 expression, along, with negative regulation of Bcl-2 gene (Abbas and Al-Fatlawi, 2018). In this review, 5.7% (n = 4) of the studies that tested carvacrol or thymol showed that they were able to increase in vitro JNK phosphorylation in colon cancer (Fan et al., 2015; Chauhan et al., 2018), choriocarcinoma (Lim et al., 2019) and bladder cancer (Li et al., 2017). The mechanism of action reported in in vivo studies involves slightly more complex processes. 2018, e9049252. Chan WY, Hickey EE, Khazandi M, Page SW, Trott DJ, Hill PB. J. Pharmacol. It triggers apoptosis by forming pores within the outer mitochondrial membrane, releasing cytochrome C that activates proteases such as caspase-9 and -3, that dismantle and destroy the cell (apoptosis) (Olsson and Zhivotovsky, 2011). In summary, we observed that more in vivo studies, particularly in respect of thymol, are needed. Regulation of C6 Glioma Cell Migration by Thymol. (2019), thymol produced cytotoxic effects and reduced the number of MCF-7 cells, suggesting that this monoterpene induces cell cycle arrest, probably due to p21 overexpression. (2016). Aceite de Orégano 91-95% Carvacrol. doi:10.1007/s10616-011-9389-y, Yoo, J. y., Kim, C. H., Song, S. H., Shim, B. Y., Jeong, Y. J., Ahn, M. I., et al. J. Dr Behcet Uz Child. Potential Preventive Effect of Carvacrol against Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats. Aparte de eso, también puede disolverse en soluciones alcalinas fuertes debido a su capacidad para desprotonar. Treat. University of Johannesburg, South Africa, Heidelberg University. Carvacrol Induces Reactive Oxygen Species (ROS)-mediated Apoptosis along with Cell Cycle Arrest at G0/G1 in Human Prostate Cancer Cells. Final approval of the completed manuscript: AG and DT. doi:10.1016/j.bcp.2005.10.005, Potočnjak, I., Gobin, I., and Domitrović, R. (2018). Los cromatogramas fueron elaborados en: Instituto de Investigación en Bioquímica y Biología Molecular de la UNALM, 2014. 580 (21), 4984–4990. (2018). p53 and Apoptosis. outline: none; También contiene compuestos como el carvacrol que han demostrado tener propiedades antiinflamatorias. Este último ha demostrado tener propiedades. Para la verificación de la distribución normal de los resultados, se evaluó la linealidad a través de la relación entre la concentración del timol - carvacrol y la absorbancia por el detector de FL-HPLC. Res. doi:10.1080/13543784.2019.1678583, Lee, H. S., and Park, S. W. (2016). IET nanobiotechnol. El carvacrol inhibe el crecimiento de diversas cepas de bacterias por ejemplo Escherichia coli [5] y Bacillus cereus.Se utiliza de aditivo alimentario para prevenir la contaminación bacteriana. Además, el orégano debe diluirse con aceite fraccionado de coco de PI3K-AKT-mTOR Inhibition in Cancer Immunotherapy, Redux. into BALB/c mice, which after 7–10 days (when the tumors grew to approximately 100 mm3) were treated with thymol (75 or 150 mg/kg every other day). J. However, there are still gaps regarding the standard or ideal dose, the exact mechanism of action and safety of the two compounds, revealing challenges for future studies. Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells. analyzed the research results and selected potentially relevant studies after reading their title and abstract, using the systematic review application, Rayyan (Ouzzani et al., 2016). Carvacrol Suppresses Proliferation and Invasion in Human Oral Squamous Cell Carcinoma. Molecules 26 (2), 410. doi:10.3390/molecules26020410, Carqueijeiro, I., Langley, C., Grzech, D., Koudounas, K., Papon, N., O’Connor, S. E., et al. Pode ajudar a reduzir a infecção viral Orégano.Imagem editada Tina Xinia no Unsplash. The methodological quality of the studies included revealed many items classified as “unclear” or “uncertain” indicating that the report—and presumably the experimental design—of these studies can be improved, especially with regard to the generation of the random sequence, the concealment of allocation and the blinding of researchers and evaluators, important factors in respect of a reliable result. Sci. 18 (3), e1003583. doi:10.26226/morressier.5770e29ad462b80290b4ba57, Melušová, M., Jantová, S., and Horváthová, E. (2014). doi:10.1093/molehr/4.12.1099, Bei, R., and Mizejewski, G. J. Expression of Bcl-2 and P53 in Induction of Esophageal Cancer Cell Apoptosis by ECRG2 in Combination with Cisplatin. Similarly, Melušová et al. Chem. Cancer Biol. Adv. Targeting Vascular Endothelial Growth Factor and Angiogenesis for the Treatment of Colorectal Cancer. Curr. It is estimated that one in five people worldwide faces the diagnosis of some malignant neoplasm during their lifetime, and the number of people with cancer is forecast to double by the year 2040 (World Health Organization, 2020). Rev. 4-Hydroxynonenal Induces Rat γ-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase-Mediated Electrophile Response Element/Nuclear Factor Erythroid 2-Related Factor 2 Signaling. Óleo de orégano é composto de ácido rosmarínico, carvacrol, terpenos, timol, além de outras substâncias benéficas, incluindo boro, cálcio, cobre, ferro, flavonoides, magnésio, manganês, potássio, vitaminas A, vitamina C, vitamina B3 (niacina), vitamina E e zinco. Curr. However, further in vivo studies with robust methodology are required to define a standard and safe dose, determine their toxic or side effects, and clarify its exact mechanisms of action. PloS one 8 (11), e81162. doi:10.1053/j.seminoncol.2004.09.026, Conklin, K. A. Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Phytotherapy Res. (2017). Cuando lo utilizamos de forma externa, ya sea mediante infusión de orégano o mediante alcohol o aceite de orégano, tendremos los siguientes beneficios. Timol 1294 ---- 14,3 Carvacrol + Timol 1318 53,2 ---- J-Terpineno 1068 8,2 10,0 Orégano cimarrón Lippia origanoides LOH (hojas) Cultivo experimental CENIVAM p-Cimeno 1035 10,1 9,5 Timol 1298 35,8 34,0 p-Cimeno 1035 19,5 17,7 J-Terpineno 1068 9,7 6,8 Tomillo Thymus vulgaris TOM (hojas) Cultivo experimental CENIVAM Carvacrol 1315 4,3 5,7 Timol . Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens. 2020 Apr;31(2):81-85. doi: 10.1111/vde.12807. Carvacrol-induced [Ca2+]i Rise and Apoptosis in Human Glioblastoma Cells. Como anticáncer. doi:10.1155/2020/8602879, Asif, M. (2015). Aceite de oregano que . Thymol and Carvacrol also have antibacterial properties as pure substances. (2018). El desarrollo del presente método tiene por finalidad dotar de herramientas para tomar decisiones sobre la identificación de regiones donde uno o más ecotipos pueden desarrollarse potencialmente con respecto a la calidad de sus aceites esenciales en función al contenido de timol y carvacrol. Biochem. doi:10.2174/1570161115666170105124038, Slamenová, D., Horváthová, E., Sramková, M., and Marsálková, L. (2007). Bogotá – Colombia. 39 (6), 2082–2104. In respect of breast cancer, treatment with carvacrol decreases MDA-MB231 (Jamali et al., 2018; Li et al., 2021) and MCF-7 cells line viability (Al-Fatlawi and Ahmad, 2014; Jamali et al., 2018; Tayarani-Najaran et al., 2019; Li et al., 2021). Infect. The History of Medicine. In mice, the lethal dose was 110–233.3 mg/kg, after inducing ataxia and drowsiness (Suntres et al., 2015). El carvacrol es un compuesto químico que se encuentra en los aceites esenciales de la mejorana, el orégano, el tomillo, la ajedrea y otras plantas. doi:10.1016/j.cotox.2018.08.001, Alrehaili, A. los diferencia clave entre carvacrol y timol es que el carvacrol contiene un grupo hidroxilo en la posición orto del anillo de benceno, mientras que el timol contiene un grupo hidroxilo en la posición meta del anillo de benceno. Caspases and Cancer. doi:10.1155/2016/1469693, Mari, A., Mani, G., Nagabhishek, S. N., Balaraman, G., Subramanian, N., Mirza, F. B., et al. Signal Integration by JNK and P38 MAPK Pathways in Cancer Development. A narrative summary of the results is presented below, divided into in vitro and in vivo studies. Ind. Treatment Decisions and Survival for People with Small-Cell Lung Cancer. Health 34 (8), 525–539. Límites de detección y cuantificación. *:focus-visible { Similarly, most of the SYRCLE tool domains for animal studies (random sequence generation; baseline characteristics; allocation concealment; blinding of caregivers and researchers; random evaluation of results; blinding of the results evaluator) were classified as uncertain due to the lack of information in the articles. Acamc 17 (14), 1942–1950. In addition, treatment with this monoterpene promoted an accumulation of cells in the sub-G1 phase, indicating that changes in intracellular calcium and ROS generation are related to the antiproliferative effects observed. In fact, both may be involved in a possible antitumor mechanism of carvacrol, but it is still not very clear, requiring further studies (Li et al., 2019). Cytotechnology 43 (1–3), 149–154. (2017). However, 97% of the studies applied the same conditions (temperature and incubation time, and purity, stability) for in vitro assays, ensuring a low risk of bias (Figure 3). Cytotoxic Effect of Carvacrol on Human Cervical Cancer Cells. Anticancer Drugs 26 (8), 813–823. J. Biol. (2014) also evaluated the effect of carvacrol pre- and post-treatment on a DEN-induced hepatocarcinogenesis rat model and observed a stability in tumor marker levels, a reduced mast cell density and inhibition of cell proliferation. Estos valores son similares a los encontrados para Origanum x aplii and Origanum x majoricum donde el timol presenta valores de 33,8 y 12,9 %, respectivamente y para el carvacrol se encontró valores menores a 1,0 % 12. Un sinónimo de este compuesto es cymophenol. (2018). Tanto el carvacrol como el timol tienen la misma fórmula química (C10H14O), pero tienen estructuras ligeramente diferentes. (2020) also identified the cytotoxic effects of thymol on AGS cell viability, in addition to inducing apoptosis, by increasing ROS, Bax, Caspase-3, -9 levels and reducing Bcl-2 and GSH levels. Em Portugal, o óleo essencial é conhecido como óleo de orégão e em países de língua inglesa como oregano oil. Reprod. 1998. 360 (1–2), 51–60. Forty-three used carvacrol, 19 thymol, and 15 studies tested both monoterpenes. Methodology (CPMP/ICH/281/95) London: ICH Topic Q2B, Validation of Analytical Procedures. Ingresa a tu cuenta para ver tus compras, favoritos, etc. Similarly, thymol had a promising protective efficacy, revealing a chemopreventive effect against colon cancer observed by the increase in GST, GSH, SOD and CAT levels, in addition to inhibiting oxidative stress (Hassan et al., 2021). Mercado Libre Argentina - Donde comprar y vender de todo. 60, 619–642. Involvement of apoptosis in carvacrol and thymol treatment in cancer. PLoS ONE 14 (9), e0222629. (2013). Carvacrol showed cytotoxic effects against human myeloid leukemia cells (K-562 cell line) (Horvathova et al., 2007; Jaafari et al., 2012) and against T-cell acute lymphoblastic leukemia (CEM cell line) (Jaafari et al., 2012). Ther. Perry LR, MacLennan B, Korven R et al. Krelin et al. The Effect of Carvacrol on Apoptosis of H-RAS and N-RAS Transformed Cell Lines. 1996. O orégano possui alta atividade antioxidante pela presença de ácido fenólico e flavonoides, além de propriedades antimicrobianas contra a bactéria Listeria monocytogenes e outros patógenos presentes nos alimentos, o . Las dos estructuras se diferencian entre sí según la posición del grupo hidroxilo. CASPASE-8 Gene Is Inactivated by Somatic Mutations in Gastric Carcinomas. Política De Privacidad | El método ha presentado una linealidad mayor a 0,999, precisión ≤ 2,27 y 2,4 intra día, y ≤ 2,47 y 1,94 inter diario para el carvacrol y timol, respectivamente. In a way, it can be seen that the studies in this area do not seem to evolve toward a specific target, with low complementarity of the screenings carried out in vitro for the studies developed with experimental animals. PC-3 cells also exhibited cytotoxicity and decreased cell viability in a concentration dependent manner after carvacrol treatment (Horng et al., 2017). doi:10.1016/j.bmcl.2018.06.044, Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S. S., et al. 2011; 43 (1): 237-245. Anticancer Res. ERK is generally associated with cell proliferation, while JNK and p38 are closely related to the cell death process (Wagner and Nebreda, 2009). Neoplasma 54 (2), 108–112. National Cancer Institute (2019). Pathania, A. S., Guru, S. K., Verma, M. K., Sharma, C., Abdullah, S. T., Malik, F., et al. Origanum majorana e Origanum dictamnus são ricas em carvacol, 50% e 60-80% respectivamente. Harvest Time and Geographical Origin Affect the Essential Oil of Lippia Gracilis Schauer. Carvacrol tiene un esqueleto de monoterpeno y es parte del grupo funcional fenoles. Editors S. Zahra Bathaie, and F. Tamanoi (Cambridge: Academic Press), 1–258. Regulatory Roles of MAPK Phosphatases in Cancer. Functions of the MAPK Family in Vertebrate-Development. doi:10.1016/j.lfs.2012.03.027, Lim, W., Ham, J., Bazer, F. W., and Song, G. (2019). FOIA ¿Cuál es la diferencia entre carvacrol y timol. Cancer Lett. It was revealed in the study by Hassan et al. Effect of Thymol on Ca^(2+) Homeostasis and Viability in PC3 Human Prostate Cancer Cells. There was also inhibition of HCT116, LoVo and HT-29 cells proliferation (Fan et al., 2015; Pakdemirli et al., 2020). MMP‐2 and MMP‐9 as Prognostic Markers for the Early Detection of Urinary Bladder Cancer. Potential and Use of Bacterial Small RNAs to Combat Drug Resistance: a Systematic Review. Adicionalmente o carvacrol também activa, mas rapidamente dessensibiliza, o receptor de dor TRPA1; tal explica a sua pungência. Cuantificación por Cromatografía Líquida de Alta Resolución. Accessibility O óleo de orégano também auxilia no tratamento de gripes e resfriados, febre leve, menstruação dolorosa, além de ser útil no tratamento de uma série de infecções causadas por bactérias. Overexpression of MMP-2 in Laryngeal Squamous Cell Carcinoma: a Potential Indicator for Poor Prognosis. IUBMB Life 71 (2), 166–176. Es wirkt sich positiv auf den gesamten Prozess der Wundheilung, aus. J Microbiol Biotechnol. Palabras clave: Orégano, timol, carvacrol, aceites esenciales, HPLC. carvacrol oregano emulsificado Ordenar por Más relevantes Aceite Esencial De Oregano Natier 30ml 70% Carvacrol 3140 pesos$3.140 Primal Fx Oregano Oil 80% Carvacrol Timol. Proibida a cópia ou reprodução sem autorização prévia. Corona-Gómez L, Hernández-Andrade L, Mendoza-Elvira S, Suazo FM, Ricardo-González DI, Quintanar-Guerrero D. Int J Vet Sci Med. Lett. Available at: https://www.inca.gov.br/estimativa/introducao (Acesseced November 13, 2020). RÉSULTATS: L'huile d'origan, l'huile de thym, le carvacrol et le thymol ont montré une activité antibactérienne contre toutes les souches bactériennes et fongiques testées. Effect of Thymol on Ca2+ Homeostasis and Viability in Human Glioblastoma Cells. Unable to load your collection due to an error, Unable to load your delegates due to an error. doi:10.1038/sj.cr.7290257, Zeng, L. P., Hu, Z. M., Li, K., and Xia, K. (2016). Se determinó la identidad de los componentes de la muestra en base a los tiempos de retención de los estándares puros. Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. Chemical Composition and In Vitro Activity of Origanum Vulgare L., Satureja Hortensis L., Thymus Serpyllum L. And Thymus Vulgaris L. Essential Oils towards Oral Isolates of Candida Albicans and Candida Glabrata. They are matrix degradation enzymes (such as MMP), responsible for the degradation of the main constituents of basement membrane and extracellular matrix, facilitating the invasion of tumor cells and favoring the spread of cancer cells and metastases (Nagase et al., 2006; Shuman Moss et al., 2012; Jabłońska-Trypuć et al., 2016). Estos aceites esenciales y sus principales componentes fenólicos tienen el potencial de ser investigados in vivo para el tratamiento de la otitis externa canina. Cancer Res. doi:10.3892/etm.2016.385010.3892/etm.2016.3850, Wang, X., and Wang, Q. 10 (1), 61–64. doi:10.1515/hsz-2013-0128, Hooijmans, C. R., Rovers, M. M., De Vries, R. B., Leenaars, M., Ritskes-Hoitinga, M., and Langendam, M. W. (2014). In contrast, post-treatment with carvacrol demonstrated the presence of small persistent nodules, loss of cellular architecture and a lower tendency to spread through the intrahepatic veins. (1982). La apicultura y el timol El timol como aceite esencial es muy usado el la apicultura y la cría de abejas, esto debido a que este aceite esencial es usado para combatir organismos más . Instituto de Salud Pública. Cancer Res. Natural compounds can regulate caspase-9 expression, and, therefore, favor apoptosis in cancer (Kim et al., 2015). Thymol Induces Mitochondrial Pathway-Mediated Apoptosis via ROS Generation, Macromolecular Damage and SOD Diminution in A549 Cells. ¡Descargá gratis la app de Mercado Libre! 23 (4), 310–319. Aceites que se mezclan bien con aceite de Orégano Involvement of the MAPK pathway in carvacrol and thymol treatment in cancer. 9 (5), 294–299. Caseros 3039, Piso 2, CP 1264, Parque Patricios, CABA. TOR Signaling in Growth and Metabolism. 9. doi:10.1038/sj.onc.1202490, Tayarani-Najaran, Z., Akaberi, M., Hassanzadeh, B., Shirazi, N., Asili, J., Al-Najjar, H., et al. Al considerar las reacciones del carvacrol, la oxidación con cloruro férrico puede convertir el carvacrol en dicarvacrol y la oxidación con pentacloruro de fósforo lo convierte en clorcimol. Nat. También existe uno de extracto de tomillo rojo al 100% que contiene timol y aparte carvacrol este puede ayudar a tratar las plantas que contengan hongos. An update from the Infectious Diseases Society of America. Les valeurs de MIC90 allant de 0.015 à 0.03% (146-292 μg/mL) pour la bactérie Gram-positive et P. mirabilis. Thermo Fisher Scientific, Germering, Germany; 1 -2, 2013. These essential oils and their main phenolic constituents have the potential to be further investigated in vivo for the treatment of canine otitis externa. In addition, some inhibitors of this signaling pathway have already been approved by the Food and Drug Administration for cancer treatment (Alzahrani, 2019). Toxicol. On the other hand, AFU indicates clinical prognosis of several malignant tumors and helps to diagnose primary hepatocarcinoma (Giardina et al., 1992), colorectal cancer (Ayude et al., 2000), ovarian cancer (Abdel-Aleem et al., 1996), and was recently identified as an effective new biomarker for squamous cell carcinoma of the early esophagus (Yu et al., 2019). Significance and impact of study: In the wake of rising antimicrobial resistance, we envisage that carvacrol and thymol could be used to prevent biofilm formation by UPEC and to reduce its virulence. Depois de 24 horas, apenas se detectaram quantidades muito pequenas de carvacrol ou dos seus metabolitos na urina, indicando uma excreção quase completa ao fim de um dia. El carvacrol es un compuesto orgánico que tiene la fórmula química C10H14O. PC-3 cells demonstrated greater sensitivity to treatment with thymol compared to DU145 cells. É um óleo espesso que assenta a 20 °C numa massa de cristais com ponto de fusão 0 °C, e ponto de ebulição 236–237 °C. (2017). Regarding thymol (50 µM), the KG1 cell line was also more sensitive when compared to the other two and at the 100 µM dose, thymol was able to induce complete cell death in the KG1 and HL60 cell lines (Bouhtit et al., 2021). [3], O carvacrol está presente no óleo essencial do orégão (Origanum vulgare), no óleo de tomilho, óleo obtido de espécies do género Lepidium e em Monarda fistulosa O óleo essencial de subespécies de tomilho podem conter entre 5% e 75% de carvacrol, enquanto que subespécies de Satureja têm um conteúdo entre 1% e 45%. Editors A. Bishayee, and D. Bhatia (Cambridge: Academic Press), 205–229. doi:10.1038/nrc1187, Seresht, H. R., Albadry, B. J., Al-mosawi, A. K. M., Gholami, O., and Cheshomi, H. (2019). [7] Em Pseudomonas aeruginosa causa danos à membrana celular e, ao contrário de outros terpenos, inibe a sua proliferação. According to the industry interested, the quality of oregano is measured by the concentration of carvacrol and thymol (secondary metabolites). In addition, the TRPM7 pathway is one of the suggested pharmacological mechanisms of action (Li et al., 2021). 2017 Mar 28;27(3):429-438. doi: 10.4014/jmb.1608.08024. Oregano oil, thyme oil, carvacrol and thymol exhibited antibacterial activity against all bacterial and fungal isolates tested. En el presente trabajo se validó el método de determinación por HPLC con detector de Fluoresencia de timol y carvacrol en muestras de Origanum vulgare, bajo las condiciones mencionadas en el artículo, utilizando la linealidad, límites de detección y cuantificación, selectividad, precisión, recuperación 1,9,10. In human laryngeal squamous cell carcinomas (Hep), thymol showed a pronounced reduction of cell proliferation and also apoptosis, at a concentration of 30.5 ng/mL. 92, 491–500. i.id = "GoogleAnalyticsIframe"; Páginas para editores sem sessão iniciada saber mais, O carvacrol, ou cimofenol, C6H3CH3(OH)(C3H7), é um monoterpeno fenólico. In vitro antimicrobial effect of essential tea tree oil(. Moreover, genotoxic effects have been shown to be exhibited by carvacrol (Günes-Bayir et al., 2018) and thymol (Günes-Bayir et al., 2018), and it was also shown that a high concentration of carvacrol (460 µM) exhibited mutagenic and genotoxic effects causing DNA damage (Llana-Ruiz-Cabello et al., 2015). Semin. Chem. J. Hepatol. (2014). Se determinó la concentración de los componentes de la muestra a partir de la curva de calibración por regresión lineal y luego se llevó a masa de la hoja. Pharmacognosy Magazine; 2010; 6 (23): 154-158. 15 (4), 339–351. Minyak Oregano mengandung senyawa penting yang disebut carvacrol, yang memiliki sifat antimikroba. The development of this method is essential to provide tools for decision making to identify regions where one or more ecotypes can potentially grow and produce high quality of essential oils contents of thymol and carvacrol. Transl Oncol. J. Med. Medicinal Plants for Women's Healthcare in Southeast Asia: A Meta-Analysis of Their Traditional Use, Chemical Constituents, and Pharmacology. 274, 119335. doi:10.1016/j.lfs.2021.119335, Hassen, A. M., Taye, G., Gizaw, M., and Hussien, F. M. (2019). Expression of γ-glutamyltransferase in Cancer Cells and its Significance in Drug Resistance. Chin. (2018), Günes-Bayir et al. A., et al. 35 (2011), 735–742. Aquí están algunas de las propiedades que lo hacen muy útil. Oregano (Origanum vulgare L.) is an aromatic native plant originated from the Mediterranean region and it's traditionally grown in the south of Peru. Cytotoxicity and Pro-apoptotic Activity of Carvacrol on Human Breast Cancer Cell Line MCF-7. doi:10.5772/50277, Song, H.-Y., Deng, X.-H., Yuan, G.-Y., Hou, X.-F., Zhu, Z.-D., Zhou, L., et al. 19 (4), 191–199. β-hémolytique (n = 20), Pseudomonas aeruginosa (n = 20; comprenant 10 souches résistantes à un ou deux antimicrobiens), Proteus mirabilis (n = 20) et Malassezia pachydermatis (n = 20) de chiens avec otite externe. Available at: https://www.springer.com/gp/book/9781588297488 (Acesseced December 21, 2020). An accumulation of cells in the G0/G1 phase was observed, along with a reduction of cells in the S and G2 phases, mainly through the reduced expressions of CDK4, CDK6, retinoblastoma protein (pRB), cyclin D and phosphoinositide-3-kinase-Akt (PI3K/p-AKT) (Mari et al., 2020). Pharmacol. In murine B16-F10 and A375 melanoma cell lines, carvacrol reduced cell viability and induced cytotoxicity (Satooka and Kubo, 2012; Ferraz et al., 2013; Govindaraju and Arulselvi, 2018). Os valores de MIC90 variaram entre 0,015 e 0,03% (146-292 μg/mL) para as bactérias Gram-positivas e P. mirabilis. Rev. doi:10.21037/jtd.2019.08.92, Zarubin, T., and Han, J. Analysis of the Essential Oils of Five Artemisia Species and Evaluation of Their Cytotoxic and Proapoptotic Effects. doi:10.1016/B978-0-12-802215-3.00002-1, Shuman Moss, L. A., Jensen-Taubman, S., and Stetler-Stevenson, W. G. (2012). Phytotherapy Res. H. Hajimehdipoor, M. Shekarchi, M. Khanavi, N. Abid, M. Amri, A validated high performance liquid chromatography method for the analysis of thymol and carvacrol in Thymus vulgaris L. volatile oil. Oxidative Med. Un poco de aceite de orégano en la dieta también apoya la pérdida de grasa corporal no deseada. Es un isómero estructural del carvacrol porque el carvacrol tiene su grupo hidroxilo en la posición para mientras que el timol tiene su grupo hidroxilo en la posición meta. Rev. Effects of Carvacrol on Human Fibroblast (WS-1) and Gastric Adenocarcinoma (AGS) Cells In Vitro and on Wistar Rats In Vivo. MIC90 values ranged from 0.015 to 0.03% (146-292 μg/mL) for the Gram-positive bacteria and P. mirabilis. J. The inhibition of cell proliferation and apoptosis on MDA-MB231 and MCF-7 cell lines occurred via the mitochondrial pathway and induction of oxidative damage to DNA through Bax/Bcl-2 modulation, decreased levels of procaspase-8, -9, -3, increased levels of cleaved caspase-3 and ROS, and also cell cycle arrest at S-phase (Jamali et al., 2018). Commun. CDK4/6 Inhibition in Breast Cancer: Current Practice and Future Directions. Remarkably, ten studies did not report the source of the tested compounds. Res. 18 (1), 108–118. The purpose of this systematic review was to answer the following question: Do carvacrol and thymol exhibit an anti-tumor effect on cancer cells (in vitro) or in animal models of cancer? 234 (2), 1803–1815. Both are monoterpenoid phenols, the main components present in essential oils obtained from several plant species of the Lamiaceae and Verbenaceae families, such as oregano (Origanum vulgare L.), thyme (Thymus vulgaris L.) and “alecrim-da-chapada” (Lippia gracilis) (Santos et al., 2016; Salehi et al., 2018; Sharifi-Rad et al., 2018; Baj et al., 2020), which have already been reported to exhibit beneficial effects against many diseases (Silva et al., 2018), including cancer (Elbe et al., 2020; Pakdemirli et al., 2020). Thymol seems to act more against gastric cancer carcinoma (AGS, IC50 = 75.63 μM, Günes-Bayir et al., 2018). It was possible to verify that, in general, carvacrol (336.7 ± 35.0, n = 21) is more potent than thymol (527.1 ± 146.6, n = 11), with difference between means of 103.8 (±106.9). También podemos producir carvacrol sintéticamente mediante la fusión de ácido cymol sulfónico en presencia de potasa cáustica. Treatment with carvacrol (100 μM) showed early and late apoptotic cells accompanied by a reduction of mitochondrial membrane potential levels, suggesting that apoptosis was mediated by the mitochondrial pathway, with a significant increase of Bax pro-apoptotic proteins, decreased expression of the anti-apoptotic proteins Bcl2 and an increased caspase-3 protein level (Bhakkiyalakshmi et al., 2016). Berlin: Springer, 185–232. Diagnostic and Therapeutic Implications of the Vascular Endothelial Growth Factor Family in Cancer. PubChem . In addition, carvacrol showed a greater cytotoxicity compared to thymol against murine mast cell cells (P-815 cell line) (Jaafari et al., 2007; Jaafari et al., 2012), with accumulation of cells in the S phase (Jaafari et al., 2012). Osguthorpe JD, Nielsen DR. Otitis externa: review and clinical update. Effect of Thymol on Peripheral Blood Mononuclear Cell PBMC and Acute Promyelotic Cancer Cell Line HL-60. Targeting HIF-1 for Cancer Therapy. Med. For the colorectal cancer model, HCT116 xenograft was injected (i.p.) En cuanto a las propiedades físicas de este compuesto, tiene el distintivo olor acre y cálido del orégano. Genet. The induction of PC-3 cells apoptosis was mostly through the intrinsic pathway, associated with the production of ROS and mediated by the increase expression of caspase-3, -8 and -9 and Bcl-2/Bax. and L.T.S.P.) According to the results found by Seresht et al. É relacionado ao carvacrol, possuindo a mesma fórmula molecular, porém os átomos estão dispostos de forma diferente. 50 (1), 271–276. 181 (6), 1895–1899. Hum. 19 (11), 902–912. 2 (10), 1218–1223. (2021) demonstrated the potential of these monoterpenes in the control of gastric carcinoma by reducing the viability of AGC cells. Thus, it is necessary to consider the studies already carried out for these compounds before conducting new primary studies on this topic, in order to evolve the research stages to the next level of drug development: in vivo studies and clinical trials. Plants Omics Journal; 2011; 4(4): 209-214. Role of Fruit and Vegetable in the Treatment of Cancer. 48, 91–103. (2011). 120 (5), 8169–8176. 1. Oncol. Chin. Cancer Sci. [13] con modificaciones. doi:10.1371/journal.pone.0135078, PubMed Abstract | CrossRef Full Text | Google Scholar, Ahmed, H., Shousha, W., El-Mezayen, H., Ismaiel, N., and Mahmoud, N. (2013). De hecho, esta sustancia podría disminuir un poco los niveles de colesterol y triglicéridos de la sangre. Comparación lado a lado: carvacrol frente a timol en forma tabular 5. (2018). doi:10.1177/1534735404270335, Dabrowska, C., Li, M., and Fan, Y. Cold Spring Harbor Perspect. daenensis Celak. University of Johannesburg, South Africa, Heidelberg University, This article is part of the Research Topic, https://doi.org/10.3389/fphar.2021.702487, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=176736, https://www.frontiersin.org/articles/10.3389/fphar.2021.702487/full#supplementary-material, https://www.inca.gov.br/estimativa/introducao, http://www.who.int/publications/10-year-review/en/, https://www.springer.com/gp/book/9781588297488, https://www.who.int/publications/i/item/who-report-on-cancer-setting-priorities-investing-wisely-and-providing-care-for-all. Wagner, E. F., and Nebreda, Á. R. (2009). Effect of Thymol on Ca2+ Homeostasis and Viability in MG63 Human Osteosarcoma Cells. Conclusions et importance clinique: Rep. 73 (1), 240–254. Thymol Elicits HCT-116 Colorectal Carcinoma Cell Death through Induction of Oxidative Stress. (2016). The following combination of health descriptors, MeSH terms and their synonyms were used: carvacrol, thymol, antitumor, antineoplastic, anticancer, cytotoxicity, apoptosis, cell proliferation, in vitro and in vivo. El timol pertenece al grupo de los terpenos. Para P. aeruginosa e M. pachydermatis, os valores de MIC90 variaram de 0,09 a 0,25% (800-2,292 μg/mL). El orégano (Origanum vulgare L.) es una planta aromática originaria del mediterráneo; tradicionalmente es cultivada en la zona sur del Perú. doi:10.3892/ol.2016.4237, Li, D., Yang, M., Liao, A., Zeng, B., Liu, D., Yao, Y., et al. FIGURE 4. Rev. Alpha Fetoprotein Is More Than a Hepatocellular Cancer Biomarker: from Spontaneous Immune Response in Cancer Patients to the Development of an AFP-Based Cancer Vaccine. doi:10.1080/10408398.2011.653458, Swanton, E., Savory, P., Cosulich, S., Clarke, P., and Woodman, P. (1999). 1,3,6,7 la cromatografía de gases es muy útil para realizar el análisis cualitativo y cuantitativo de todos los componentes no volátiles del aceite … (2014). The expression of caspase-9 was the second most reported in this review, due to its crucial role in apoptosis initiation among various types of cancer (Kim et al., 2015). Podemos encontrar carvacrol de forma natural en los aceites esenciales de orégano, tomillo, pepperwort y bergamota silvestre. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. (2017). In vitro antibacterial activity of the manuka essential oil from Leptospermum scoparium combined with Tris-EDTA against Gram-negative bacterial isolates from dogs with otitis externa. Oncol. O timol inibe a capacidade de algumas bactérias se aderirem a células humanas, dispondo de um mecanismo antimicrobiano que rompe a parede celular bacteriana e faz com que citoplasma vaze. Biomed. Safety and Tolerability of Carvacrol in Healthy Subjects: a Phase I Clinical Study. 20 (3), 559–567. Cent souches bactériennes et fongiques ont été utilisées, comprenant Staphylococcus pseudintermedius sensible à la méticiline (n = 10), S. pseudintermedius résistante à la méticiline (n = 10), Streptococcus spp. A significant reduction in cancer growth, a greater number of necrotic lesions and a lower level of Ki-67 expression were observed, which reflects cell proliferation. doi:10.1517/14728222.2014.961425, Kim, C., and Kim, B. As for the lung metastasis model, HCT116 cells were injected into the tail vein of each mouse and then received treatment with thymol (75 or 150 mg/kg every other day). Recibido 30-09-2014 Aprobado 19-11-2014,  Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons, Av. 266, 118894. doi:10.1016/j.lfs.2020.118894, Li, S., Zhao, H., and Bao, L. (2019). In addition, 9 studies were identified after a manual search of the references and two studies obtained from other sources, but only seven studies were added (two studies were excluded for having a mixture between carvacrol and thymol, one for being associated with other substances, and one that studied the extract of a plant rich in thymol), finally resulting in 77 included studies (Figure 1). MARNYS® Oregamar Bio contiene un mínimo de 60% de carvacrol y 4% de timol. Gelatinolytic Activity of Matrix Metalloproteinase-2 and -9 in Oesophageal Carcinoma; a Study Using In Situ Zymography. (2017). In this review, it was noted that three in vitro studies (4.4%) reported that carvacrol decreased CDK4 protein expression in human tongue squamous cell carcinoma (Tca-8113 cells) (Dai et al., 2016) and in breast cancer (MCF-7 cells) (Mari et al., 2020; Li et al., 2021) and only one (1.4%) reported a decrease in CDK6 in MCF-7 cells (Mari et al., 2020).
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